Whitepaper
Crystallization in the Pharmaceutical Process
November 2022
- Biopharma
- Bioreactors
- Data-Logging
- Parallel Reactions
- Reactors
Crystallization is explored through its four main types—cooling, anti-solvent, reactive, and pH-controlled—along with examples and key applications. The role of impurities, seeding strategies, and process control are emphasized, as well as the importance of PAT, DoE, and QbD in optimizing outcomes. Scale-up considerations and the value of crystal structure analysis and modeling are also highlighted.
Author: Radleys
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Used Products
Reactor-Ready Filter Lab Reactor
Reaction and filtration in a single jacketed vessel setup, ideal for crystallisation, reaction workups, and product isolation.
Mya 4 Reaction Station Kit
A flexible discovery tool for single or parallel synthesis, lead or reaction optimization, reagent, catalyst, and solvent screening.